Pneumatic dry granulation（2）
Source： | Date:
2011-09-15
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1. Introduction
Granulation is a common unit operation in the manufacture of solid dosage forms to improve the properties of powders. According to Kristensen and Schaefer, the purpose of wet or dry granulation in pharmaceutical dosage form manufacture is to:
1) Improve powder flow properties for dosage filling and compression processes.
2) Eliminate wet granulation-induced degradation and improve product stability.
3) Prevent segregation.
4) Reduce bulk volume thereby minimizing storage volume and improving transport efficiencies.
5) Reduce potential environmental and safety hazards using either high-shear mixing or fluid-bed processing. However, dry granulation has recently increased in popularity.
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