1.1    Dry granulation through RC is gaining popularity. The most common dry granulation technique is roller compaction (RC) that is combined with the consequent gentle milling of the flakes. Although the RC process has been in use for many years, it has lately become increasingly popular, and its use in pharmaceutical solid dosage from processing has grown considerably. Whilst having all the benefits a gran-ulation process can provide, including the improvement of material flow behavior and content uniformity, RC also offers advantages over wet granulation regarding moisture, solvent or heat sensitivity of the drug substance. According to Miller and Sheskey, the increasing scale of manufacturing of pharmaceutical products worldwide, the need for high processing rates, increased levels of good manufacturing practices, together with a desire to reduce manufacturing complexity means that RC is an increasingly attractive option for the manufacture of oral solid dosage forms. These authors continue by stating that this has been accomplished by instrumenting roller compactors to automate and control the mechanical process. Furthermore, RC technology plays a very important role in providing competitive cost control because of its high throughput at a minimum of operator presence and floor space, and last but not least, RC-based dry granulation scale up efforts are minimized. Key RC benefits observed have been compiled.