Pneumatic dry granulation(4)
Source: | Date:
2011-11-03
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RC is a continuous dry granulation process with the aim of manufacturing free flowing granulate, increasing the bulk density and ensuring the uniformity of particulate formulations by preventing the segregation of the constituents of the
powder. In RC, a powder blend is compacted between two counter-rotating rolls. In the narrow region of the gap between the rolls, the powder is subjected to pressure, leading.
This ribbon is then reduced in size using dry milling to achieve the desired granule size. The main purpose is to obtain granulate with acceptable flow properties and sufficient secondary compactibility for the subsequent processing steps, typically tableting or encapsulation. The theory of compaction and RC is not covered in this review but provided elsewhere [3,5]. Successful use of RC has been demonstrated in the development and production of conventional immediate release solid dosage forms [6-9] as well as for controlled release drug delivery systems.
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